the frequency of interleukin-10 (il-10) polymorphisms in patients with peptic ulcer and chronic gastritis

نویسندگان

میثم رضایی شهمیرزادی

meysam rezaeishahmirzadi ندا معتمدی راد

neda motamedi rad سید حمید موسوی

seyed hamid moosavy محمد شکاری

mohammad shekari

چکیده

abstract introduction: peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. it has been shown that helicobacter pylori infection is related with inflammatory responses of gastric mucosa. however, some patients remain asymptomatic. sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. the aim of this study is to investigate the genetic polymorphisms of inflammatory cytokine il-10 and its relationship with peptic ulcer and gastric inflammation. correspondence: mohammad shekari, md, phd. molecular medicine research center, hormozgan university of medical sciences. bandar abbas, iran tel:+98 76 33354939 email: [email protected] methods: in this study, 107 people with symptoms of stomach pain and indigestion referred to a doctor with an indication for endoscopy were selected as the patient group. 107 healthy people without complications such as stomach pain and indigestion were selected as the control group. il-10-592a/c polymorphism was examined by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp). results: no significant difference was found between the patients with peptic ulcer and chronic inflammation and healthy people in the control group in terms of the c allele in the il-10 gene (p=0.99; 0.48-1.80, ci 95%, or 0.93, and p=0.26; 0.57-1.13, ci 95%, or 0.81, respectively). conclusion: the results showed no significant correlation between the inflammatory cytokine il-10 gene polymorphisms and peptic ulcer disease and chronic inflammation.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis

ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The a...

متن کامل

Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1...

متن کامل

The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population

Background and Objective: The current study aimed at assessing the relationship between gastritis and peptic ulcer susceptibility and inflammation-related gene polymorphisms in Iranian patients. Gastritis and peptic ulcer are common medical complications with serious outcomes on the quality of life. Inflammatory responses of gastric mucosa are associated with helicobac...

متن کامل

IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage

Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...

متن کامل

study of il-10, il-18 polymorphisms in the sulfur agent patients with and without periodontitis

background and aims . periodontitis is a multifactorial disease. varieties of microbial and environmental, as well as genetic factors are reported to influence risk for periodontitis. the present study sought to test the putative involvement of il-10 and il-18 gene polymorphism in pre-disposition to periodontitis in patients had exposure to chemical agent as a risk factor for periodontitis deve...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
hormozgan medical journal

جلد ۲۰، شماره ۴، صفحات ۲۸۹-۲۹۴

کلمات کلیدی
[ ' p o l y m o r p h i s m ' , ' i n t e r l e u k i n ' , 1 0 , ' p e p t i c u l c e r ' , ' c h r o n i c g a s t r i t i s ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023